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18 Publication(s) en 2010 (1847 dans la base de données)
Farid K, Meissner WG, Samier-Foubert A, Barret O, Menegon P, Rouanet F, Fernandez P, Orgogozo JM, Allard M, Tison F, Sibon I. Normal cerebrovascular reactivity in stroke-like migraine attacks after radiation therapy syndrome.
Clin Nucl Med. 2010 Aug;35(8):583-5. 2010
original article. IF : 3.915
Liens vers résumé
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| Unité |
Imagerie moléculaire et fonctionnelle : de la physiologie à la thérapie - Chrit Moonen ; Mouvement - Adaptation - Cognition - Jean-René Cazalets ; Pôle de Neurosciences cliniques - Jean-Marc Orgogozo |
| Equipe |
Thérapies guidées par imagerie et Imagerie moléculaire - Chrit Moonen ; Physiopathologie des syndromes parkinsoniens - Erwan Bezard ; Service de médecine nucléaire - Michèle Allard ; Service de Neuroradiologie diagnostique et thérapeutique - Vincent Dousset |
| Abstract |
Stroke-like Migraine Attacks after Radiation Therapy (SMART) syndrome is a rare complication of cranial irradiation. Radiation is well-known to impair vascular vessel architecture and function. We investigated the hypothesis of radiation-induced cerebral vascular reserve dysfunction as the underlying mechanism of SMART. Interictal cerebrovascular reactivity was investigated using Tc-99m hexamethylpropyleneamine oxime-SPECT and acetazolamide challenge in 3 patients. We found interictal hypoperfusion and normal cerebrovascular reactivity in all patients. Neither ictal restriction of the apparent diffusion coefficient nor MR angiography abnormalities were observed. These findings do not support a vascular mechanism in SMART syndrome. Postradiation neuronal dysfunction may be the underlying mechanism. Further investigations on larger series are needed to confirm this hypothesis. |
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Jerome D, Dehail P, Daviet JC, Lamothe G, De Sèze MP, Orgogozo JM, Mazaux JM.
Stroke in the under-75S: Expectations, concerns and needs.
Ann Phys Rehabil Med. 2009 Aug 19. [Epub ahead of print]. 2009
Liens vers résumé
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| Unité |
Handicap et système nerveux : Physiopathologie, analyse et restauration de fonction - Pierre-Alain Joseph ; Pôle de Neurosciences cliniques - Jean-Marc Orgogozo |
| Equipe |
Handicap, systèmes cognitifs et communication - Jean-Michel Mazaux |
| Collaboration nationale |
- Neurovascular Unit, Department of Clinical Neurosciences, Academic Hospital of Bordeaux, 33076 Bordeaux cedex, France
- Rehabilitation Medicine Unit, Jean-Rebeyrol Hospital, Academic Hospital of Limoges, 87042 Limoges cedex, France |
| Abstract |
Most studies of functional outcomes in hemiplegic stroke patients use standard disability rating scales (such as the Barthel Index). However, planning the allocation of assistance and resources requires additional information about these patients' expectations and needs. AIMS OF THE STUDY: To assess functional independence in daily living and house holding, changes in home settings, type of technical aid and human helps, and expectations in hemiplegic patients 1 to 2 years after the stroke. METHODS: Sixty-one out of 94 patients admitted to the neurovascular unit of French university hospital for a first-ever documented stroke were consecutively enrolled. The study was restricted to patients under 75, since patients over 75 do not follow the same care network. Patients were examined at their homes or interviewed by phone 17 months (on average) after the stroke. Standard functional assessment tools (such as the Barthel Index and the instrumental activities of daily living [IADL] score) were recorded, along with descriptions of home settings and instrumental and human help. Lastly, patients and caregivers were asked to state their expectations and needs. RESULTS: Although only one person was living in a nursing home after the stroke, 23 (34%) of the other interviewees had needed to make home adjustments or move home. Seven patients (11%) were dependent in terms of the activities of daily living (a Barthel Index below 60) and 11 (18%) had difficulty in maintaining domestic activities and community living (an IADL score over 10). Although the remaining patients had made a good functional recovery, 23 were using technical aids and 28 needed family or caregiver assistance, including 23 patients with full functional independence scores. Twenty-five patients (42%) were suffering from depression as defined by the diagnosis and statistical manual of mental disorders (4th edition, text revision, DSM IV-R). The patients' prime concerns were related to recovery of independence, leisure activities and financial resources. Family members' expectations related to the complexity of administrative matters, lack of information and the delay in service delivery. DISCUSSION AND CONCLUSION: In under-75 hemiplegic stroke patients, high scores on standard disability rating scales do not always mean that no help is required. |
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Sibon I, Ménégon P, Orgogozo JM, Asselineau J, Rouanet F, Renou P, Tourdias T, Pachai C, Chêne G, Dousset V. Inter- and intraobserver reliability of five MRI sequences in the evaluation of the final volume of cerebral infarct. J Magn Reson Imaging. 2009 Jun;29(6):1280-4.. 2009
original article. IF : 2.209
Liens vers résumé
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| Unité |
Imagerie moléculaire et fonctionnelle : de la physiologie à la thérapie - Chrit Moonen ; Neurobiologie des affections de la myéline - Klaus Petry ; Pôle de Neurosciences cliniques - Jean-Marc Orgogozo |
| Equipe |
Neurosciences cognitives humaines et neuro-imagerie - Michèle Allard ; Neurobiologie des affections de la myéline - Klaus Petry ; Service de Neuroradiologie diagnostique et thérapeutique - Vincent Dousset |
| Collaboration nationale |
- INSERM Neuroepidemiology U-593, University Bordeaux 2, France
- CHU Bordeaux, Clinical Epidemiology Unit, INSERM, CIC-EC 7, Bordeaux, France
- Theralys Diagnostic & Therapeutic Image Analysis in Clinical Trials, Lyon, France
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| Abstract |
PURPOSE: To evaluate the reproducibility of fluid attenuated inversion recovery (FLAIR) and four other magnetic resonance imaging (MRI) sequences in the quantitative assessment of final cerebral infarct volume. MATERIALS AND METHODS: FLAIR, T1-3D, magnetization transfer ratio (MTR)-map, diffusion-weighted trace (DWI)-trace, and apparent diffusion coefficient (ADC)-map, were acquired and measured in 33 patients 30-45 days after onset of a first-ever ischemic stroke. The infarct area was visually detected and manually delineated two times by two readers separately after images and sequences randomization. The reliability was assessed by using an intraclass correlation coefficient (ICC) and its two-sided 95% confidence interval (95% CI). RESULTS: DWI-trace had the best reliability, with an ICC of 0.96 (95% CI = 0.93-0.98). FLAIR had an ICC of 0.86 (95% CI = 0.73-0.93), and a much higher volume. T1-3D, MTR-map and ADC-map had lower reliability or excessive volume values equal to 0 in comparison to DWI-trace. CONCLUSION: DWI-trace performed within 30th and 45th day following onset of acute ischemic stroke was the most reliable sequence for final infarct volume quantification. This sequence should be added to FLAIR evaluation to strengthen the statistical results of the pharmacological trials and reduce their variability. |
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Sibon I, Rouanet F, Meissner W, Orgogozo JM. Use of the Triage Stroke Panel in a neurologic emergency service. Am J Emerg Med. 2009 Jun;27(5):558-562. 2009
original article. IF : 1.164
Liens vers résumé
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| Unité |
Imagerie moléculaire et fonctionnelle : de la physiologie à la thérapie - Chrit Moonen ; Mouvement - Adaptation - Cognition - Jean-René Cazalets ; Pôle de Neurosciences cliniques - Jean-Marc Orgogozo |
| Equipe |
Neurosciences cognitives humaines et neuro-imagerie - Michèle Allard ; Physiopathologie des syndromes parkinsoniens - Erwan Bezard ; Service d'Explorations fonctionnelles du système nerveux - Pierre-Michel Burbaud |
| Abstract |
BACKGROUND: Acute stroke is associated with serum elevations of numerous markers. We evaluated the additive accuracy of the Triage Stroke Panel (D-dimer, B-natriuretic peptide, matrix metalloproteinase 9, and S-100beta) to the triaging nurse for acute stroke diagnosis. METHODS: Consecutive patients with suspected stroke were included in this prospective, controlled, single-center study. A well-trained stroke center triage nurse assigned a probability that the patient had experienced a stroke (certain, very probable, probable, not likely, doubtful, or other); then, the Triage Stroke Panel testing was performed. Patients' diagnosis was based on clinical and imaging data by a neurologist blinded to the test results. RESULTS: Two hundred four patients were evaluated. Confirmed strokes and transient ischemic attacks (TIAs) were observed in 131 patients. When considering an experienced stroke nurse's assessment of "other," "doubtful," or "not likely" to be negative for stroke and categorizing TIA with stroke, the stroke panel's Multimarker Index (MMX) value had identical accuracy ( approximately 70%) and equivalent sensitivity ( approximately 94%) and specificity ( approximately 24%) for stroke diagnosis to that of the nurse. Combining nurse assessment with the MMX result significantly improved the specificity of diagnosing "mimic" vs stroke + TIA from 25.4% (nurse assessment only) to 46.0% (nurse assessment + MMX; P < .001). CONCLUSIONS: The Triage Stroke Panel provides objective information that complements a triage nurse in the assessment of a suspected stroke patient. Its performance compares favorably with that of a well-trained stroke center triage nurse, suggesting potential use in nonexpert centers for improving the accuracy of stroke diagnosis. |
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| Dartigues JF, Helmer C, Peres K, Cowppli Bony P, Auriacombe S, Orgogozo JM. Early Prevention at Public Health Issue.
J Nutr Health Aging. 2008;12(1):84S-85S.. 2008 |
| Unité |
Fédération des Neurosciences Cliniques - M. Barat et J-M. Orgogozo |
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Tourdias T, Dousset V, Sibon I, Pele E, Menegon P, Asselineau J, Pachai C, Rouanet F, Robinson P, Chene G, Orgogozo JM. Magnetization Transfer Imaging Shows Tissue Abnormalities in the Reversible Penumbra.
Stroke. 2007 Oct 25; [Epub ahead of print]. 2007
IF : 5.391 |
| Unité |
Fédération des Neurosciences Cliniques - M. Barat et J-M. Orgogozo |
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Sibon I, Coupry I, Menegon P, Bouchet JP, Gorry P, Burgelin I, Calvas P, Orignac I, Dousset V, Lacombe D, Orgogozo JM, Arveiler B, Goizet C. COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke.
J Urol. 2004 Jan;171(1):251-5. . 2007
IF : 8.051 |
| Unité |
Fédération des Neurosciences Cliniques - M. Barat et J-M. Orgogozo |
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Carcaillon L, Peres K, Pere JJ, Helmer C, Orgogozo JM, Dartigues JF. Fast Cognitive Decline at the Time of Dementia Diagnosis: A Major Prognostic Factor for Survival in the Community.
Dement Geriatr Cogn. 2007 Apr 26; 23(6):339-345. 2007
original article. IF : 2.603 |
| Unité |
Fédération des Neurosciences Cliniques - M. Barat et J-M. Orgogozo |
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Pérès K, Chrysostome V, Fabrigoule C, Orgogozo JM, Dartigues JF, Barberger-Gateau P. Restriction in complex activities of daily living in MCI: impact on outcome.
J Urol. 2004 Jan;171(1):251-5. . 2006
IF : 5.690 |
| Unité |
Fédération des Neurosciences Cliniques - M. Barat et J-M. Orgogozo |
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| Cowppli-Bony P, Dartigues JF, Orgogozo JM. [In Process Citation]
J Urol. 2004 Jan;171(1):251-5. . 2006 |
| Unité |
Fédération des Neurosciences Cliniques - M. Barat et J-M. Orgogozo |
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