Neurosciences bordeaux
Home page Search Researchers Students ITA Teams Platforms Labs FENS themes Program areas Publications fr - en
inserm Planar Polarity and Plasticity
Research team Mireille Montcouquiol    
Associate team leader: Nathalie Sans  

Affiliated with the lab: Magendie Neurocenter - Pathophysiology of neural plasticity - Pier Vincenzo Piazza
Team leader:
Mireille Montcouquiol
Associate team leader:
Nathalie Sans
Neurocentre Magendie
Physiopathologie de la plasticité neuronale
Université Bordeaux
146, rue Léo Saignat
33077 Bordeaux cedex
Tel : +33 05 57 57 36 62
Fax : +33 05 57 57 36 69
Gestion :

The focus of our research: The general aim of our team research is to investigate the molecular basis of the physiopathology of planar cell polarity (PCP) in mammals.
Researchers, University Professor, Hospital Practitioners: Mireille Montcouquiol - Nathalie Sans -
Post-doctoral researchers: Jéröme Ezan - Maïté Moreau -
Technical and administrative staff: Marie-Claude Donat - Léa Lasvaux - Chantal Medina -
Doctorant students: Steve Dos Santos Carvalho - Muna Hilal - Vera Lucia Pinheiro - Benjamin Robert -

Program areas:
Neurobiology of development
FENS Themes:
Development / Axonal and dendritic development ; Synaptic transmission and excitability / Intracellular signalling pathways ; Synaptic transmission and excitability / Cytoskeleton ; Sensory systems ; Neurological and psychiatric conditions / Developmental disorders
Scientific expertise:
Cellular and molecular biology ; epithelial cells ; axonal growth cone ; actin cytoskeleton ; post-synaptic density (PSD) ; development ; PDZ domains ; hippocampus ; protein/protein interactions ; KO mouse model (Knockout transgenic mouse) ; cellular motility ; organ of Corti ; synaptic plasticity ; planar cell polarity (PCP) ; SAP102 protein ; adhesion proteins (cadherin, IgCAMS, integrin) ; scaffolding proteins ; NMDA receptors ; intracellular traffic in neurons
Technical expertise:
molecular biology - in situ hybridation ; molecular biology- estern blot ; molecular biology RT-PCR ; Yeast Two-Hybrid Screening ; cellular and organotypic culture ; dissection ; in situ hybridization ; cellular imaging ; immunocytochemistry ; immunohistochemistry ; cellular neurobiology
epithelial cells ; epithelium ; apicobasal polarity ; Planar cell polarity (PCP) ; inner ear ; organ of Corti ; vestibular and cochlear sytems
Inserm; Grant Marie Curie; Région Aquitaine et FRM : équipement; DGS ; ANR 2007 (NeuroScribe); ANR 2008 (vango); ANR PlanFriz 2010-2013 (en collab., porteur Cécile Duplaa INSERM U 828).
Publications: Clic here
Research projects:
The planar cell polarity (PCP) signaling pathway was first identified in the fruitfly Drosophila, ; Other animal models have demonstrated how this signalling pathway may be directly relevant to human biology and pathologies. Mutations in PCP genes have been linked, directly or indirectly, to pathologies in the central nervous system (neural tube defect, mental retardation), the sensory systems (hearing, balance, vision) the tissue homeostasis (polycystic kidney disease), or even cardiac malformation.
The aim of this project is a better understanding of the mechanisms involved in planar polarity in mammals and the identification of other involved proteins and their interactions to set the planar polarity.
  Conception et administration : C. Latié - © Développement web : Olivier Bertoncello Data Consulting