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cnrs Physiology of glutamatergic synapses
Research team Christophe Mulle    
Affiliated with the lab: Interdisciplinary Institute for Neuroscience - Daniel Choquet
 
Team leader:
Christophe Mulle
Web Site
 
Address:
Institut interdisciplinaire de Neurosciences
CNRS UMR 5297
Université Bordeaux
146, rue Léo-Saignat
33077 Bordeaux cédex
 
Administration:
Tel : +33 05 57 57 40 80
Fax : +3305 57 57 40 82
 
Gestion :
Arlette Ledo mail
Phone: 33 (0)5 57 57 40 80

 
image  
 
The focus of our research: The group is interested in excitatory synaptic transmission in the brain, and more precisely on the mechanisms of synaptic plasticity and synaptic integration in the hippocampus, a brain region involved in spatial memory.WE combine these physiological studies with cell biological approaches to understand how glutamate reeptors of the kainate and NMDA types are targeted and stabilized at synaptic sites, in particular during post-natal development, in physiological conditions and in models of mental retardation and epilepsy.
Researchers, University Professor, Hospital Practitioners: Thierry Amédée - Christophe Blanchet - Mario Carta - Christophe Mulle - Sandrine Pouvreau - Nelson Rebola -
Post-doctoral researchers: Gael Bartet - Mariela Escande - Ashley Kees -
Technical and administrative staff: Fanny Bernadou - Séverine Deforges - Noelle Grosjean - Julie Rumi Masante -
Doctorant students: Dario Cupolillo - Ania Goncalves - Nan Jiang - Tomas Jorda-Siquier - Meryl Malezieux - Pei Zhang -

Program areas:
Synapse
Neurobiology of development
 
FENS Themes:
Development / Synaptogenesis and activity-dependent development ; Synaptic transmission and excitability / Ligand gated ion channels ; Synaptic transmission and excitability / Synaptic transmission ; Synaptic transmission and excitability / Intracellular signalling pathways ; Synaptic transmission and excitability / Synaptic plasticity ; Synaptic transmission and excitability / synaptic maturation ; Neurological and psychiatric conditions / Epilepsy ; Neurological and psychiatric conditions / Developmental disorders
 
Scientific expertise:
hippocampus ; calcium imaging ; post-natal synaptic maturation ; synaptic plasticity ; glutamate receptors ; synapse ; animal models ; Intracellular trafficking of synaptic proteins
Technical expertise:
image analysis ; molecular biology ; cellular and organotypic culture ; real time dynamic of membrane receptors ; morphologic and functional imaging ; confocal microscopy ; electrophysiology in vitro ; electrophysiology in brain slices ; gene targeting with lentiviral vectors
 
Keywords:
electrophysiology ; epilepsy ; excitotoxicity ; hippocampus ; Cellular and molecular imaging ; synaptic maturation ; physiopathology ; physiopathology ; synaptic plasticity ; adhesion proteins ; synapse ; synaptogenesis ; receptor trafficking ; kainate receptor ; glutamate receptor ; mental retardation ; Alzheimer's disease
 
Collaborations:
- Trafic et fonction des récepteurs kaïnate Jeremy Henley, Bristol University, UK (EU consortium GRIPANNT); Yael Stern-Bach, Jerusalem University, Israël (EU consortium EUSynapse); Giovanni Marsicano, CRI, Bordeaux; John Isaac, NIH, Bethesda, US; - Integration et plasticité synaptique des synapses des fibres moussues de l'hippocampe Rodrigo Cunha, Coimbra University, Portugal; Jacques Micheau, CNIC, CNRS, Bordeaux; Yoon Cho CNIC, CNRS, Bordeaux; - Mécanismes cellulaires de la maturation synaptique pendant le développement postnatal du réseau CA3 Tomi Taira, Helsinki University, Finland; Michela Matteoli, CNR, University of Milan, Italy (EU consortium EUSynapse); Eckart Gundelfinger, Leibinz Institute for Neurobiology, Magdeburg, Germany (EU consortium Synscaff); - Implication des récepteurs kainate dans l'excitotoxicité et l'épilepsie Lars Christian Ronn, Neurosearch, Denmark (EU consortium GRIPANNT).
 
Contracts:
Partenariat régional: CRA 2009: Choquet, D., Sibarita, J.B., Mulle, C., Thoumine, O., L. Groc., Nägerl, V. "Nouvelles approches pour l’étude de la communication neuronale et accompagnement du développement de nouvelles équipes dans le cadre du projet d’Institut Interdisciplinaire de Neurosciences". Partenariat national : -ANR 2008-2011 MossyGlu (porteur C Mulle); - ANR Synaptic zinc 2008-2011 (porteur P. Paoletti) ; ANR SynGen 2009-2012 (porteur L. Fagni); ANR KAREP (2010-2013) (coord C. Mulle), ANR SynflAD (2011-2014) (coord C Mulle) ; - FRC-Rotary intern. 2009 (achat microscope à très haute résolution); ANR 2009-2012 MossyGlu (porteur C Mulle); CNRS; Conseil Régional Aquitaine. Partenariat européen : EU grant SYNSCAFF (STREP, EU 6th Framework Program, 2004-2007); - EU grant GRIPANNT (STREP, EU 6th Framework Program, 2005-2008); -EU grant EUSynapse (IP, EU 6th Framework Program, 2005-2009) ; KARTRAF 2009-2011 (porteur C. Mulle).
 
Publications: Clic here
 
Research projects:
- Trafficking and function of kainate receptors
- Integration and synaptic plasticity of hippocampal mossy fiber synapses
- Cellular mechanisms of synaptic maturation during postnatal development of the CA3 network
- Involvement of kainate receptors in excitotoxicity and epilepsy
 
 
 
 
     
 
  Conception et administration : C. Latié - © Développement web : Olivier Bertoncello Data Consulting