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cnrs Pathophysiology of parkinson's syndrome
Research team Erwan Bezard    
Affiliated with the lab: Neurodegenerative Diseases Institute - Erwan Bezard
 
Team leader:
Erwan Bezard
Web Site
 
Address:
Institut des maladies neurodégénératives
CNRS UMR 5293
Université de Bordeaux
Bât 3B 1er étage
146 rue Léo Saignat

33076 Bordeaux cedex
 
Administration:
Tel : +33 05 57 57 16 85
Fax : +33 05 56 90 14 21
 
Gestion :
Eric Wattelet mail
Phone: +33 (0)5 57 57 15 18

Secretarial 1:
Chantal Guérin mail
Tel : +33 05 57 57 15 40
 
 
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The focus of our research: Our team aims at understanding the molecular and cellular mechanisms responsible for the motor symptoms in Parkinson’s disease, the atypical parkinsonian syndromes (20% of total parkinsonian syndromes) and their modified response to L-dopa. Our goal is to identify therapeutic targets on the basis of pathophysiological investigations in cellular and animal models as well as on human tissus. We then validate those hits as potential clinically-relevant therapeutic targets.
Researchers, University Professor, Hospital Practitioners: Erwan Bezard - Eric Boué-Grabot - François Bourre - Benjamin Dehay - Pierre-Olivier Fernagut - Clément Jimenez - Marie-Laure Martin-Negrier - Karine Massé - Wassilios Meissner - François Tison - Anne Vital -
Post-doctoral researchers: Fares Bassil - Simone Bido - Mathieu Bourdenx - Olatz Pampliega - Federico N. Soria -
Technical and administrative staff: Marie-Hélène Canron - Evelyne Doudnikoff - Sandra Dovero - Sandrine Dupouy - Alain Estager - Alexandra Foubert-Samier - Betty François - Morgane Gaboreau - Leslie-Ann Largitte - Audrey Martinez - Marie-Laure Thiolat - Sandrine Villars -
Doctorant students: Lucie Chansel-Debordeaux - Borbala Duray - Paul-Arnaud Guérin - Juliette Uranga Chauvel -

Program areas:
Normal and pathological motor control
Neuropsychopharmacology and therapeutics of the deficiencies - transverse axis.
 
FENS Themes:
Motor systems / Basal ganglia
 
Scientific expertise:
movement disorders ; multiple system atrophy ; clinical expertise ; preclinical expertise ; Parkinson's disease ; animal models ; drug development
Technical expertise:
molecular anatomy ; immunohistochemistry ; laser microdissection ; electron microscopy ; light microscopy
 
Keywords:
Parkinson's disease ; multiple system atrophy ; dyskinesias ; molecular anatomy ; behavior ; dysregulation syndrome ; dopamine
 
Collaborations:
- Collaboration locales : B. Basse-Cathalinat (INSERM U443), D. Choquet et C. Mulle (CNRS UMR 5091), C. Lubetzki (INSERM U711). - Collaborations nationales : E. Brouillet (CNRS-CEA URA2210, Orsay), M. Holzenberger (INSERM U515, Paris), M. Jaber (CNRS 6187, Poitiers), J.L. Nahon (CNRS UMR411, Sophia Antipolis), M. Savasta (INSERM U704, Grenoble), P. Vernier (CNRS UPR 2197, Gif sur Yvette). - Collaborations internationales : A. Abeliovich (Columbia University, New York, USA), P. Andren (Uppsala University, Suède), A. Bjorklund (Lund University, Lund, Suède), R. Brambilla (San Raffaele Institute, Milano, Italy), J. M. Brotchie (University of Toronto, Canada), A. Cenci (Lund University, Lund, Suède), M.F. Chesselet (UCLA, Los Angeles, USA), A. Crossman (University of Manchester, Angleterre), Y. Du (Indiana University, Indianapolis, USA), P. Garris (Illinois State University, USA), G. Fisone (Karolinska Institute, Stockholm Suède), S. Gold (University of Texas, Dallas, USA), B. Hengerer (Boehringer, Monheim, Germany), E. Gurevich (Vanderbilt Unversity, Nashville, USA), P. Kahle (LAPDR, Munich, Germany), J. L. Lanciego (University of Navarra, Spain), M. Morari, (Univeristy of Ferrara, Ferrara, Italie), E. Nestler (University of Texas, Dallas, USA), J. Obeso (University of Pamplona, Pamplona, Spain), C. Piu (Xanwu Hospital, Beijing, China), S. Przedborski (Columbia University, New York, USA), A. Richter (Humboldt University, Berlin, Allemagne), H. Stark (Goethe University, Frankfurt, Allemagne), C.H. Taï (Taiwan National Hospital, Taipei, Taiwan), G. Wenning (Neurological Institute, Innsbruck, Austria), G. Wong (University of Kuopio, Kuopio, Finlande), B.-L. Zhao (Chinese Academy of Sciences, Beijing, China).
 
Contracts:
Michael J Fox Foundation for Parkinson Research 2006, FRC, Fondation de France, Région Aquitaine, Programme Aquitaine-Navarre, France Parkinson, Fondation NRJ, UCB, Boehringer Ingelheim; FRC 2008, Michael J Fox Foundation for Parkinson research 2008, FRC-Rotary intern. 2008 "Symptôme non-moteurs de la maladie de Parkinson". TrAFinLID ANR 01/01/2008 au 31/12/2011 Projets européens : - FP7-ICT-2009-5: NEUWalk - Neuroprosthetic interface systems for restoring motor functions. - FP7-PEOPLE-2009-IEF: PrimLID-Priming for L-dopa-induced dyskinesia and neurotransmitter. - FP7-PEOPLE-2009-ERG: AGELYSPARK - Role of the lysosomal dysfunction during aging, and implication for Parkinson’s Disease; Fondation de France 2011; Association France Parkinson 2012; FRC 2008-2011; Fondation Cariplo 2011; Michael J. Fox- Foundation for Parkinson's research 2009,2010,2011; Assoc. France EKBOM 2011,2012; CRA Recherche 2010-2014; CRA coop Aquitaine/Emilie Romagne 2012-2014 PRIMLID-7PCRD Marie Curie intra europ Fellowwship/ E Bézard 01/06/10 au 31/05/12 NEUWALK PCRD7 01/06/2010 au 31/05/2014 AGELYSPARK PCRD7-MARIE CURIE-PERSONNE-2009-ERG 03/12/2010 au 02/12/2013 -
 
Valorisation:
Industry consulting
- Start-up Motac
Not-for-profit foundations consulting
Involvement in Motac Neuroscience and Motac Cognition, CROs for movement disorders and cognitive disorders, respectively
 
Publications: Clic here
 
Research projects:
Using behavioural, functional anatomical, biochemical and molecular approaches, we aim at understanding the pathophysiology of the main feature of parkinsonian syndromes, the hypokinesia/bradykinesia, and of its response to L-dopa as well as of the L-dopa-induced side effects such as dyskinesia (LID) and dystonia. We specifically aim at unravelling the mechanisms underlying the priming phenomenon. This phenomenon reflects the property of a single administration of a dopamimetic drug to markedly modify the cellular and behavioural responses to further administrations. We also investigate the progressive loss of L-dopa response in atypical parkinsonism. Our research projects involve the use of non-human primate (macaque) and human brains (human brain bank) but also of several state-of-the-art rodent (mouse, rat, hamster) and in vitro models.
 
 
 
 
     
 
  Conception et administration : C. Latié - © Développement web : Olivier Bertoncello Data Consulting