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inserm Endocannabinoids and neuroadaptation
Research team Giovanni Marsicano    
Affiliated with the lab: Magendie Neurocenter - Pathophysiology of neural plasticity - Pier Vincenzo Piazza
Team leader:
Giovanni Marsicano
Neurocentre Magendie
Physiopathologie de la plasticité neuronale
Université Bordeaux
146 rue Léo Saignat
33077 Bordeaux cédex
Tel : +33 05 57 57 36 37 56
Fax : +33 05 57 57 36 69
Gestion :

The focus of our research: We are interested in the molecular mechanisms, which contribute to modulate neuronal activity and behaviour. In particular, we are interested in the endocannabinoid system (ECS), which is emerging as one of the most important neuronal modulator in the brain. The involvement of the ECS in many brain functions, such as the regulation of food intake and energy balance, of fear responses, of memory and the control of neuronal excitability.
Researchers, University Professor, Hospital Practitioners: Giovanni Benard - Francis Chaouloff - Giovanni Marsicano -
Post-doctoral researchers: Arnau Busquets-Garcia - Federico Massa - Isabelle Matias - Roman Serrat -
Technical and administrative staff: Astrid Cannich - José Cruz -
Doctorant students: Michelangelo Colavita - Tifany Desprez -

Program areas:
Normal and pathological cognition
Vunerability and drug addiction
Neuropsychopharmacology and therapeutics of the deficiencies - transverse axis.
Nutrition and brain
FENS Themes:
Cognition and behaviour / Animal cognition and behaviour ; Neurological and psychiatric conditions / Neurodegenerative disorders ; Autonomic, limbic and other systems / Regulation of food intake and body weight ; Autonomic, limbic and other systems / Stress and the brain
Scientific expertise:
cannabinoids ; endocannabinoid system ; anxiety ; cognitive et behavioural analysis of learning and memory processes ; food intake ; extinction of fear ; epilepsy ; degenerative disease
Technical expertise:
transgenic mice ; conditional knock-out ; conditional overexpression ; fear conditioning ; passive or active avoidance ; molecular biology ; immunohistochemistry ; in situ hybridization ; cellular neurobiology ; cellular imaging
endocannabinoid system ; conditional mutagenesis ; anxiety ; fear ; energy balance
- Collaboration locales : Pier-Vi Piazza/Veronique Deroche/Monique Vallée (INSERM U862); Daniela Cota (U862); Daniel Choquet (CNRS UMR); Stéphane Oliet (U862); Olivier Manzoni/Pascale Chavis (U862); - Collaborations nationales : Jean-Antoine Girault (INSERM Paris). - Collaborations internationales : Beat Lutz (Germany); Carsten Wotjak (Germany); Uberto Pagotto (Italy); Manuel Guzman (Spain); Rohini Kuner (Germany); Daniele Piomelli (Irvine, USA); Ken Mackie (USA); Walter Zieglgänsberger (Germany).
AVENIR INSERM in partnership with the Fundation Bettencourt (2006) ; ANR Neurosciences, neurologie et psychiatrie 2006 : « PRESYNAPTIC-CB1; ANR Neurosciences, neurologie et psychiatrie 2006 ; European Foundation for the Study of Diabetes (EFSD), 2007; Eni-Net; 2010: ERC Starting Grant for his project "Endofood" (1,5 million€)
Publications: Clic here
Research projects:
Our research project aims at understanding the molecular basis of behavioural adaptation. Our everyday behaviour are constantly adapted to environmental changes, resulting in proper responses to different challenges. The endocannabinoid system is strategically fitted to provide this important function in the brain and in the body.
  Conception et administration : C. Latié - © Développement web : Olivier Bertoncello Data Consulting