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cnrs Coordination and Plasticity of Spinal Generators
Research team Sandrine Bertrand    
Affiliated with the lab: Cognitive and Integrative Neuroscience - Aquitaine Institute - Jean-René Cazalets
 
Team leader:
Sandrine Bertrand
Web Site
 
Address:
CNRS UMR 5287 - INCIA
Institut de Neurosciences cognitives et intégratives d'Aquitaine
Université
Bordeaux
Bât. 2A- 3e étage-Case 22
146 rue Léo Saignat
33076 Bordeaux cedex
 
Administration:
 
Gestion :

Phone: 33 (0)5 57 57 15 26

 
 
Researchers, University Professor, Hospital Practitioners: Gregory Barrière - Sandrine Bertrand - Jean-René Cazalets - Maurice Garret - A. Goullet-de-Rugy - Laurent Juvin - Didier Morin - Julien Morlier -
Post-doctoral researchers: M. Husson -
Technical and administrative staff: Emma Bestaven - E. Doat - Etienne Guillaud - Christophe Halgand -
Doctorant students: Lauriane Beliez - G. Dominguez - Zhuowei Du - P. Faucher - Léa Milan - T. Prevost -

Program areas:
Normal and pathological motor control
Synapse
 
FENS Themes:
Motor systems / Locomotion ; Motor systems / Spinal cord ; Motor systems / Motoneurons ; Motor systems / Brain stem ; Sensory systems / Anatomy
 
Scientific expertise:
rhythmic activities ; functional interactions CPGs (locomotion and respiration) ; neuronal networks ontogenesis ; post-traumatic motor recuperation ; development
Technical expertise:
electrophysiology ; patch-clamp electrophysiology ; extra- and intra-cellular electrophysiology ; neuropharmacology of motor system ; functional neuroanatomy ; models of spinal cord lesion
 
Keywords:
locomotion ; neural network ; spinal cord ; sensori-motor loop ; connecting CPGs ; electrophysiology ; spinal cord lesion ; functional neuroanatomy ; mammal ; post-traumatic recuperation
 
Publications: Clic here
 
Research projects:
Our project aims to study mammalian spinal neural networks involved in motor functions. Two major themes emerge from this project. Firstly, we investigate the cellular and synaptic mechanisms which allow the various neuronal networks engaged in rhythmic (such as locomotion and respiration) and non-rhythmic (such as posture) motor activities to operate independently or together as they necessarily do during normal behavior. In this context, we seek to determine i) the key elements of neural networks responsible for generating or modulating locomotor output patterns, and ii), the mechanisms involved in locomotor-postural control and locomotor-respiratory couplings. Second, we explore the plastic capabilities of the ventral spinal cord that contains the neural circuitry responsible for posture and locomotion under both physiological and pathological conditions. To this end, we investigate the activity-dependent plasticity of excitatory and inhibitory synapses onto lumbar motoneurons during normal development and following spinal cord injury. A combination of in vitro and in vivo experimental approaches are employed mainly in rodents (neonatal, juvenile and adult rat and mouse), and a part of our project is conducted on humans.
 
 
 
 
     
 
  Conception et administration : C. Latié - © Développement web : Olivier Bertoncello Data Consulting