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  Xavier Leinekugel
Researcher PhD
Neurocentre Magendie
Physiopathologie de la plasticité neuronale
Université Bordeaux
146, rue Léo Saignat
33077 Bordeaux cedex
Phone: +33 (0)5 57 57 37 04
Fax: +33 (0)5 57 57 36 69

Mail du chercheur: mail
tel: 33 (0)6 09 55 53 39
  More information
Cortical plasticity mechanisms in normal and pathological conditions - Andreas Frick  
  Program areas:
Normal and pathological cognition

FENS Themes:
Development / Synaptogenesis and activity-dependent development ; Synaptic transmission and excitability / synaptic maturation ; Synaptic transmission and excitability / Synaptic plasticity ; Synaptic transmission and excitability / Ligand gated ion channels ; Neurological and psychiatric conditions / Epilepsy ; Neurological and psychiatric conditions / Developmental disorders ; Development / Axonal and dendritic development

Scientific expertise:
electrophysiology ex vivo ; electrophysiology in vitro ; electrophysiology in vivo ; hippocampus ; calcium imaging ; receptors interaction ; post-natal synaptic maturation ; animal models ; memory and memory system ; Genetic mouse models in psychiatric diseases ; neuroanatomy of hippocampus ; neurotransmission ; synaptic plasticity ; long-term potentiation ; receptors of GABA ; glutamate receptors ; metabotropic glutamate receptors ; NMDA receptors ; neural networks ; biological rhythms ; sleep ; synapse ; synaptogenesis ; cognition disorders ; development ; neuromodulation ; neural plasticity ; development disorders

Technical expertise:
encoding / decoding of neural activity ; quantitative EEG ; electrophysiology ; patch-clamp electrophysiology ; animal electrophysiology in bevavioral situation ; electrophysiology ex vivo ; electrophysiology in vitro ; electrophysiology in vivo ; multichannels multisites electrophysiology ; electrophysiology in brain slices

rythmic activities ; cognition ; network dynamics ; electrophysiology ; epilepsy ; hippocampus ; sensory-motor integration ; synaptic maturation ; memory and memory system ; experimental animal model ; neurobiology ; neurophysiology ; neuropathology ; synaptic transmission disturbances ; physiopathology ; physiopathology ; synaptic plasticity ; rat ; glutamate receptor ; GABA receptor ; kainate receptor ; reward ; neural network ; rodent ; sleep ; mouse ; synapse ; synaptogenesis ; synaptic transmission ; cognition disorders ; aging
Research interests: Using electrophysiological recordings in rats and mice from several dozens of neocortical and hippocampal neurons at the same time, we try to understand how local microcircuits are functionnally organized, interact and participate in various cognitive behaviors. Recording from immature animals, we also investigate the effects of neuronal activity on the building of cortical circuits during development.
Research projects: - examine cellular and network interactions in vitro and in vivo to identify the organization of neocortical and hippocampal circuits in adult rats. Particular emphasis is put on the synaptic interactions between pyramidal glutamatergic cells and GABAergic interneurons within the hippocampal microcircuit. - examine the spike times and patterns of activity in the hippocampus and neocortex in vivo, during various behaviors (space coding, replay of activity during sleep...) to understand information coding and storage within behaving cortical networks. - characterize and manipulate (in vitro and in vivo) the patterns of activity expressed in developing cortical structures from rats and transgenic mice conditionnally expressing mutations associated to human neuronal diseases, in order to understand the relationships between immature neuronal patterns and the building of functional adult cortical circuits.
Publications: Clic here
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