||I have focused my research on the neural bases of Human hemispheric specialization (HS) in relation with cognition. With my colleagues we have completed the BIL&GIN project (Brain Imaging lateralization & GIN, Mazoyer 2015), an acquired neuroimaging /psychometric/DNA database of 453 healthy participants, enriched to 50% of left-handers. The BIL&GIN have provided original results on HS and triggered numerous international collaborations. Initial results include reference data such as the description of the resting-state networks obtained in 430 participants (Naveau 2012); the occurrence of Heschl’s gyri duplications that, when leftward, are associated with lower leftward functional asymmetry during speech listening (Tzourio-Mazoyer 2014a and 2014b); the absence of association between MP and language lateralization, except in a small group of left-handed subjects strongly lateralized to the right for language and to the left for their preferred hand (Mazoyer 2014), opening new perspectives on genetic studies. At the regional level, we have shown that decreased lateralization is associated with increased inter-hemispheric connectivity at rest (Tzourio-Mazoyer 2015) and demonstrated that atypical individuals can be detected from intrinsic connectivity (Joliot 2016). Thanks to this dedicated database we also have evidenced a benefit to be lateralized for language, independently of the hemisphere side, and of the type of cognitive skill (Mellet 2014). We are currently acquiring the anatomical and functional brain images of 2000 students enrolled in the IShare epidemiological cohort (leader C Tzourio) in the aim of rpoviding a comprehensive characterization of this period of life where the last steps of brain maturation occurs within the frame of intense learning.