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  Muriel Thoby-Brisson
Researcher PhD
Team leader - Organization and Adaptability of Spinal Motor Systems
Institut de Neurosciences cognitives et intégratives d'Aquitaine
Université Bordeaux
Zone Nord, Bât. 2A- 2ème étage
146 rue Léo Saignat
33076 Bordeaux cedex
Phone: +33 05 57 57 15 51
Fax: +33 05 56 90 14 21

Mail du chercheur: mail
tel: 33 (0)5 57 57 47 73
  More information
Organization and Adaptability of Spinal Motor Systems - Muriel Thoby-Brisson  
  Program areas:
Normal and pathological motor control
Neurobiology of development

FENS Themes:
Motor systems / Brain stem ; Synaptic transmission and excitability / Intrinsic membrane properties ; Development / Development of sensory, motor and limbic systems

Scientific expertise:
endogenous rhythmic activities ; electrophysiology in vitro ; central pattern generator ; calcium imaging ; neuronal networks ontogenesis ; neural networks

Technical expertise:
patch-clamp electrophysiology ; electrophysiology in vitro ; calcium imaging

rythmic activities ; neural network
Research interests: Neuronal activity in the central nervous system (CNS) is functionally relevant only when motor output commands are organized and adapted to an organism's needs. Thus, at different axial levels of the CNS (cortex, brainstem, spinal cord), in order to generate complex activity patterns for behavior, neuronal assemblages are organized into discrete networks, some of which constitute rhythmically-active central pattern generators (CPGs). My research interests focus on the respiratory CPG controlling one of the most important biological functions: breathing. In mice, my previous work established a capacity for functional flexibility (i.e. the generation of multiple respiratory-related activities) that derives from different neuronal phenotypes and functional reconfiguration processes within the respiratory CPG. In a developmental approach, I also investigated the functional emergence of the respiratory CPG during embryonic development. My projects are now oriented towards the identification of the developmental mechanisms involved in the maturation of the respiratory CPG, allowing the transition from its immature embryonic state into one where its role is to ensure survival at birth through the generation of a respiratory motor command that must be both robust (to assure a vital function) and flexible (to continuously adapt to changing environmental conditions).
Research projects: Maturation of cellular, synaptic and neuromoduylatory properties of the preBötzinger complex respiratory oscillator during embryonic development
Publications: Clic here
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