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  Researcher:
 
Cota
  Daniela Cota
Researcher MD
INSERM
inserm
  Researcher
Team leader - Pathophysiology of Energy balance regulation and obesity - AVENIR Group
Address:
Neurocentre Magendie
INSERM U862
Physiopathologie de la plasticité neuronale
Université Bordeaux
146, rue Léo Saignat
33077 Bordeaux cedex
Phone: +33 (0)5 57 57 37 05 ou 06
Fax: +33 (0)5 57 57 36 69

Mail du chercheur: mail
tel: +33-(0)5-5757-3705
  Team:
Pathophysiology of Energy balance regulation and obesity - AVENIR Group - Daniela Cota  
 
  Program areas:
Vunerability and drug addiction
Nutrition and brain
Neuropsychopharmacology and therapeutics of the deficiencies - transverse axis.


FENS Themes:
Autonomic, limbic and other systems / Regulation of food intake and body weight ; Autonomic, limbic and other systems / Neuroendocrine ; Synaptic transmission and excitability / Intracellular signalling pathways

Scientific expertise:
hypothalamus ; obesity ; energy balance ; branched-chain aminoacids ; mTOR (mammalian target of rapamycin) ; cannabinoids ; endocannabinoid system

Technical expertise:
intracerebral administration ; molecular biology ; molecular biology - in situ hybridation ; molecular biology- estern blot ; molecular biology RT-PCR ; immunocytochemistry ; immunohistochemistry ; confocal microscopy ; animal models ; stereotaxy ; behavior ; behaviour analysis ; body composition analysis ; energy expenditure analysis

Keywords:
energy balance ; hypothalamus ; obesity ; branched-chain aminoacids ; mTOR (mammalian target of rapamycin) ; endocannabinoid system
   
   
 
Research interests: Our research activity focuses on understanding the pathophysiological mechanisms leading to the development of metabolic disorders, such as obesity, principally focusing on the role of the central nervous system (CNS) in this context. In particular, our laboratory studies hypothalamic neuronal circuits as well as intracellular signaling cascades that are involved in the CNS regulation of food intake and body weight. Currently, principal topics of research include the study of the role of the mammalian target of rapamycin (mTOR) signaling cascade and of the endocannabinoid system in energy balance regulation. The laboratory uses a multidisciplinary approach, including different animal models (i.e. diet-induced obese rodents, conditional and whole body knockouts), molecular strategies and analysis of behavior.
Research projects: Our research activity focuses on understanding the pathophysiological mechanisms leading to the development of metabolic disorders, such as obesity, and principally studies the role of hypothalamic neuronal circuits as well as intracellular signaling cascades in this context. Current topics of research include the role of the mTOR signaling cascade and of the endocannabinoid system in the regulation of energy balance.
Publications: Clic here
   
   
     
 
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