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34 results for: Dynamic and pathological basal ganglia
Beyeler A, Kadiri N, Navailles S, Boujema MB, Gonon F, Le Moine C, Gross C, De Deurwaerdère P. Stimulation of serotonin2C receptors elicits abnormal oral movements by acting on pathways other than the sensorimotor one in the rat basal ganglia. Neuroscience. 2010 May 3. 2010
original article. IF : 3.556
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets |
| Team |
Noyaux gris centraux, dynamiques et pathologiques - Christian Gross ; Neuropsychopharmacologie de l'addiction - Martine Cador |
| Program areas |
Fonctions motrices normales et pathologiques |
| Abstract |
Serotonin2C (5-HT(2C)) receptors act in the basal ganglia, a group of sub-cortical structures involved in motor behavior, where they are thought to modulate oral activity and participate in iatrogenic motor side-effects in Parkinson's disease and Schizophrenia. Whether abnormal movements initiated by 5-HT(2C) receptors are directly consequent to dysfunctions of the motor circuit is uncertain. In the present study, we combined behavioral, immunohistochemical and extracellular single-cell recordings approaches in rats to investigate the effect of the 5-HT(2C) agonist Ro-60-0175 respectively on orofacial dyskinesia, the expression of the marker of neuronal activity c-Fos in basal ganglia and the electrophysiological activity of substantia nigra pars reticulata (SNr) neuron connected to the orofacial motor cortex (OfMC) or the medial prefrontal cortex (mPFC). The results show that Ro-60-0175 (1 mg/kg) causes bouts of orofacial movements that were suppressed by the 5-HT(2C) antagonist SB-243213 (1 mg/kg). Ro-60-0175 (0.3, 1, 3 mg/kg) dose-dependently enhanced Fos expression in the striatum and the nucleus accumbens. At the highest dose, it enhanced Fos expression in the subthalamic nucleus, the SNr and the entopeduncular nucleus but not in the external globus pallidus. However, the effect of Ro-60-0175 was mainly associated with associative/limbic regions of basal ganglia whereas subregions of basal ganglia corresponding to sensorimotor territories were devoid of Fos labeling. Ro-60-0175 (1-3 mg/kg) did not affect the electrophysiological activity of SNr neurons connected to the OfMC nor their excitatory-inhibitory-excitatory responses to the OfMC electrical stimulation. Conversely, Ro-60-0175 (1 mg/kg) enhanced the late excitatory response of SNr neurons evoked by the mPFC electrical stimulation. These results suggest that oral dyskinesia induced by 5-HT(2C) agonists are not restricted to aberrant signalling in the orofacial motor circuit and demonstrate discrete modifications in associative territories.
Serotonin2C (5-HT(2C)) receptors act in the basal ganglia, a group of sub-cortical structures involved in motor behavior, where they are thought to modulate oral activity and participate in iatrogenic motor side-effects in Parkinson's disease and Schizophrenia. Whether abnormal movements initiated by 5-HT(2C) receptors are directly consequent to dysfunctions of the motor circuit is uncertain. In the present study, we combined behavioral, immunohistochemical and extracellular single-cell recordings approaches in rats to investigate the effect of the 5-HT(2C) agonist Ro-60-0175 respectively on orofacial dyskinesia, the expression of the marker of neuronal activity c-Fos in basal ganglia and the electrophysiological activity of substantia nigra pars reticulata (SNr) neuron connected to the orofacial motor cortex (OfMC) or the medial prefrontal cortex (mPFC). The results show that Ro-60-0175 (1 mg/kg) causes bouts of orofacial movements that were suppressed by the 5-HT(2C) antagonist SB-243213 (1 mg/kg). Ro-60-0175 (0.3, 1, 3 mg/kg) dose-dependently enhanced Fos expression in the striatum and the nucleus accumbens. At the highest dose, it enhanced Fos expression in the subthalamic nucleus, the SNr and the entopeduncular nucleus but not in the external globus pallidus. However, the effect of Ro-60-0175 was mainly associated with associative/limbic regions of basal ganglia whereas subregions of basal ganglia corresponding to sensorimotor territories were devoid of Fos labeling. Ro-60-0175 (1-3 mg/kg) did not affect the electrophysiological activity of SNr neurons connected to the OfMC nor their excitatory-inhibitory-excitatory responses to the OfMC electrical stimulation. Conversely, Ro-60-0175 (1 mg/kg) enhanced the late excitatory response of SNr neurons evoked by the mPFC electrical stimulation. These results suggest that oral dyskinesia induced by 5-HT(2C) agonists are not restricted to aberrant signalling in the orofacial motor circuit and demonstrate discrete modifications in associative territories. |
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Storvik M, Arguel MJ, Schmieder S, Delerue-Audegond A, Li Q, Qin C, Vital A, Bioulac B, Gross CE, Wong G, Nahon JL, Bezard E. Genes regulated in MPTP-treated macaques and human Parkinson's disease suggest a common signature in prefrontal cortex.
Neurobiol Dis. 2010 Mar 2.. 2010
original article. IF : 4.852
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets |
| Team |
Physiopathologie des syndromes parkinsoniens - Erwan Bezard ; Noyaux gris centraux, dynamiques et pathologiques - Christian Gross |
| Program areas |
Fonctions motrices normales et pathologiques |
| National Collaboration |
- Université de Nice-Sophia Antipolis, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097, Valbonne, France
- Biothèque Primate/Primatech, Centre National de la Recherche Scientifique Institute of the Biological Sciences (INSB), Bordeaux-Valbonne, France |
| European Collaboration |
- Department of Biosciences, Department of Neurobiology, Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland. |
| International Collaboration |
- Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing, China. |
| Abstract |
The presymptomatic phase of Parkinson's disease (PD) is now recognized as a prodromal phase, with compensatory mechanism masking its progression and non-motor early manifestations, such as depression, cognitive disturbances and apathy. Those mechanisms were thought to be strictly dopamine-mediated until recent advances have shed light upon involvement of putative outside-basal ganglia, i.e. cortical, structures. We took advantage of our progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model to monitor whole genome transcriptional changes in several brain areas. Our data reveals that transcriptomic activity changes take place from early stages, suggesting very early compensatory mechanisms or pathological activity outside the basal ganglia, including the PFC. Specific transcriptomic changes occurring in the PFC of fully parkinsonian MPTP-treated macaques have been identified. Interestingly, a large part of these transcriptomic changes were also observed in human post-mortem samples of patients with neurodegenerative diseases analysed by quantitative PCR. These results suggest that the PFC is able to detect the progression of dopamine denervation even at very early time points. There are therefore mechanisms, within the PFC, leading to compensatory alterations and/or participating to pathophysiology of prodromal PD manifestations. |
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Navailles S, Benazzouz A, Bioulac B, Gross C, De Deurwaerdère P. High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease.
J Neurosci. 2010 Feb 10;30(6):2356-64.. 2010
original article. IF : 7.452
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets |
| Team |
Noyaux gris centraux, dynamiques et pathologiques - Christian Gross |
| Program areas |
Fonctions motrices normales et pathologiques |
| Abstract |
High-frequency stimulation of the subthalamic nucleus (STN-HFS) and l-3,4-dihydroxyphenylalanine (l-DOPA) medication are the most used therapeutic approaches in Parkinson's disease (PD), but their beneficial motor effects are burdened by the emergence of cognitive and depressive disorders. Although a reduced serotonergic function has been linked to the psychiatric effects of antiparkinsonian treatments, biochemical evidence supporting this hypothesis is still lacking. By using a microdialysis approach in anesthetized rats, we investigated the ability of STN-HFS (130 Hz, 30 muA, 20 min) and l-DOPA (6-12 mg/kg) to change extracellular levels of serotonin (5-HT) monitored simultaneously in the prefrontal cortex (PFC) and hippocampus (HIPP), two brain regions involved in the regulation of mood and cognition that receive a distinct 5-HT innervation. The results show that STN-HFS inhibited 5-HT levels in the PFC and HIPP of sham-lesioned and 6-hydroxydopamine (6-OHDA)-lesioned rats. The effect elicited by STN-HFS was blocked by the administration of the 5-HT(1A) agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin. l-DOPA (6 and 12 mg/kg) reduced 5-HT levels in the PFC and HIPP of 6-OHDA rats. STN-HFS did not further decrease 5-HT levels induced by l-DOPA, but attenuated l-DOPA-induced dopamine release in the PFC and HIPP. These neurochemical data show that STN-HFS inhibits 5-HT release by modulating serotonergic neuron activity, while the decrease in 5-HT levels induced by l-DOPA may include its direct action inside serotonergic neurons. These results support the premise that antiparkinsonian treatments reduce central serotonergic transmission, which may favor the development of nonmotor side effects in PD. |
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Leblois A, Reese R, Labarre D, Hamann M, Richter A, Boraud T, Meissner WG. Deep brain stimulation changes basal ganglia output nuclei firing pattern in the dystonic hamster.
Neurobiol Dis. 2010 Feb 4. . 2010
original article. IF : 4.852
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets ; Pôle de Neurosciences cliniques - Jean-Marc Orgogozo |
| Team |
Noyaux gris centraux, dynamiques et pathologiques - Christian Gross ; Service de Neurologie - Bruno Brochet |
| Program areas |
Fonctions motrices normales et pathologiques |
| European Collaboration |
- Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, Germany
- Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Germany |
| Abstract |
Dystonia is a heterogeneous syndrome of movement disorders characterized by involuntary muscle contractions leading to abnormal movements and postures. While medical treatment is often ineffective, deep brain stimulation (DBS) of the internal pallidum improves dystonia. Here, we studied the impact of DBS in the entopeduncular nucleus (EP), the rodent equivalent of the human globus pallidus internus, on basal ganglia output in the dt(sz)-hamster, a well-characterized model of dystonia by extracellular recordings. Previous work has shown that EP-DBS improves dystonic symptoms in dt(sz)-hamsters. We report that EP-DBS changes firing pattern in the EP, most neurons switching to a less regular firing pattern during DBS. In contrast, EP-DBS did not change the average firing rate of EP neurons. EP neurons display multiphasic responses to each stimulation impulse, likely underlying the disruption of their firing rhythm. Finally, neurons in the substantia nigra pars reticulata display similar responses to EP-DBS, supporting the idea that EP-DBS affects basal ganglia output activity through the activation of common afferent fibres. |
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Navailles S, Bioulac B, Gross C, De Deurwaerdère P. Serotonergic neurons mediate ectopic release of dopamine induced by L-DOPA in a rat model of Parkinson's disease.
Neurobiol Dis. 2010 Jan 20.. 2010
original article. IF : 4.862
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets |
| Team |
Noyaux gris centraux, dynamiques et pathologiques - Christian Gross |
| Program areas |
Fonctions motrices normales et pathologiques |
| Abstract |
Benefit and motor side-effects of L-DOPA in Parkinson's disease have been related to dopamine transmission in the striatum. However, the putative involvement of serotonergic neurons in the dopaminergic effects of L-DOPA suggests that the striatum is not a preferential target of L-DOPA. By using microdialysis in a rat model of Parkinson's disease, we found that L-DOPA (3-100 mg/kg) increased dopamine extracellular levels monitored simultaneously in four brain regions receiving serotonergic innervation: striatum, substantia nigra, hippocampus, prefrontal cortex. The increase was regionally similar at the lowest dose and 2-3 times stronger in the striatum at higher doses. Citalopram, a serotonin reuptake blocker, or the destruction of serotonergic fibers by 5,7-dihydroxytryptamine impaired L-DOPA-induced dopamine release in all regions. These data demonstrate that L-DOPA induces an ectopic release of dopamine due to serotonergic neurons. The new pattern of dopamine transmission created by L-DOPA may contribute to the benefit and side effects of L-DOPA. |
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Ammari R, Lopez C, Bioulac B, Garcia L, Hammond C. Subthalamic nucleus evokes similar long lasting glutamatergic excitations in pallidal, entopeduncular and nigral neurons in the basal ganglia slice. Neuroscience. 2010 Jan 13. . 2010
IF : 3.556
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets |
| Team |
Noyaux gris centraux, dynamiques et pathologiques - Christian Gross |
| Program areas |
Fonctions motrices normales et pathologiques |
| National Collaboration |
- NMED Inserm UMR 901, Université Aix Marseille 2, 163 route de Luminy BP 13, Marseille F-13273, France |
| Abstract |
The subthalamic nucleus (STN) modulates the activity of globus pallidus (GP), entopeduncular nucleus (EP) and substantia nigra pars reticulata (SNr) neurons via its direct glutamatergic projections. To investigate the mechanism by which STN affects activity in these structures and whether STN induced activity is comparable among STN target neurons, we performed patch clamp recordings in a tilted, parasagittal, basal ganglia slice (BGS) that preserves these functional connections. We report that single, brief stimulation of the STN generates a brief monosynaptic AMPA-mediated excitatory postsynaptic current (EPSC) in GP, EP and SNr neurons. A higher intensity, supra-threshold activation evokes a compound EPSC consisting of an early monosynaptic component followed by a slow inward NMDA-mediated current with an overlying barrage of AMPA-mediated EPSCs. These late EPSCs were polysynaptic and gave rise to bursts of spikes that lasted several hundreds of milliseconds. They were eliminated by surgical removal of the STN from the BGS slice, indicating that the STN is required for their generation. Reconstruction of biocytin-filled STN neurons revealed that a third of STN neurons project intra-STN axon collaterals that may underlie polysynaptic activity. We propose that activation of the STN yields comparable long lasting excitations in its target neurons by means of a polysynaptic network. |
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De Deurwaerdère P, Le Moine C, Chesselet MF. Selective blockade of serotonin(2C) receptor enhances Fos expression specifically in the striatum and the subthalamic nucleus within the basal ganglia. Neurosci Lett. 2010 Jan 22; 469(2):251-5. 2010
original article. IF : 2.200
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets |
| Team |
Neuropsychopharmacologie de l'addiction - Martine Cador ; Noyaux gris centraux, dynamiques et pathologiques - Christian Gross |
| International Collaboration |
- Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1769, United States |
| Abstract |
Serotonin(2C) (5-HT(2C)) receptors are widely expressed in the basal ganglia, a group of brain regions involved in the control of motor behavior. However, it remains unclear whether their tonic influence on neuronal activity is distributed in these regions. We have addressed this question by measuring the product of the proto-oncogene c-Fos in rats after peripheral administration of the non-selective 5-HT antagonist mianserin, the 5-HT(2C/2B) antagonist SER-082 or the selective 5-HT(2C) antagonist SB 243213. The intraperitoneal administration of 1mg/kg of SB 243213 or SER-082, but not mianserin, enhanced Fos-immunoreactive cells in the subthalamic nucleus and the striatum, primarily its medial portion. None of these treatments significantly affected Fos expression in the external globus pallidus, the entopeduncular nucleus (the internal globus pallidus in primate) or the substantia nigra pars reticulata. The data suggest that selective blockade of 5-HT(2C) receptors is necessary to unmask a tonic regulation of neuronal activity by this receptor in the basal ganglia and that this effect is restricted to the two structures receiving cortical entries, the striatum and the subthalamic nucleus. |
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Rotge JY, Langbour N, Jaafari N, Guehl D, Bioulac B, Aouizerate B, Allard M, Burbaud P. Anatomical Alterations and Symptom-Related Functional Activity in Obsessive-Compulsive Disorder Are Correlated in the Lateral Orbitofrontal Cortex.
Biol Psychiatry. 2009 Dec 14.. 2009
original article. IF : 8.672
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets ; Imagerie moléculaire et fonctionnelle : de la physiologie à la thérapie - Chrit Moonen ; Pôle universitaire de psychiatrie adulte - H. Verdoux |
| Team |
Réseaux thalamo-corticaux et planification de l'action - Pierre-Michel Burbaud ; Noyaux gris centraux, dynamiques et pathologiques - Christian Gross ; Neurosciences cognitives humaines et neuro-imagerie - Michèle Allard |
| Program areas |
Fonctions motrices normales et pathologiques ; Fonctions cognitives normales et pathologiques |
| Abstract |
No abstract available |
| Principal Publication |
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Rotge JY, Langbour N, Guehl D, Bioulac B, Jaafari N, Allard M, Aouizerate B, Burbaud P Gray Matter Alterations in Obsessive-Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis
Neuropsychopharmacology. 2009 Nov 4. 2009
original article. IF : 6.835
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets ; Imagerie moléculaire et fonctionnelle : de la physiologie à la thérapie - Chrit Moonen ; Physiopathologie de la plasticité neuronale - Pier Vincenzo Piazza ; Pôle universitaire de psychiatrie adulte - H. Verdoux ; Pôle de Neurosciences cliniques - Jean-Marc Orgogozo |
| Team |
Réseaux thalamo-corticaux et planification de l'action - Pierre-Michel Burbaud ; Noyaux gris centraux, dynamiques et pathologiques - Christian Gross ; Neurosciences cognitives humaines et neuro-imagerie - Michèle Allard ; Physiopathologie de l'addiction - Pier Vincenzo Piazza ; Service de médecine nucléaire - Michèle Allard |
| Program areas |
Fonctions motrices normales et pathologiques ; Fonctions cognitives normales et pathologiques |
| National Collaboration |
- Service de Neurophysiologie Clinique, Centre Hospitalier Universitaire Pellegrin, Bordeaux, France
- Service Hospitalo-Universitaire de Psychiatrie Adulte, Centre Hospitalier Henri Laborit, Centre Hospitalier La Millétrie, Université de Poitiers, Poitiers, France
- Ecole Pratique des Hautes Etudes, Bordeaux, France |
| Abstract |
Many voxel-based morphometry (VBM) studies have found abnormalities in gray matter density (GMD) in obsessive-compulsive disorder (OCD). Here, we performed a quantitative meta-analysis of VBM studies contrasting OCD patients with healthy controls (HC). A literature search identified 10 articles that included 343 OCD patients and 318 HC. Anatomic likelihood estimation meta-analyses were performed to assess GMD changes in OCD patients relative to HC. GMD was smaller in parieto-frontal cortical regions, including the supramarginal gyrus, the dorsolateral prefrontal cortex, and the orbitofrontal cortex, and greater in the basal ganglia (putamen) and the anterior prefrontal cortex in OCD patients relative to HC. No significant differences were found between children and adults. Our findings indicate differences in GMD in parieto-frontal areas and the basal ganglia between OCD patients and HC. We conclude that structural abnormalities within the prefrontal-basal ganglia network are involved in OCD |
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Palminteri S, Boraud T, Lafargue G, Dubois B, Pessiglione M Brain hemispheres selectively track the expected value of contralateral options
J Neurosci. 2009 Oct 28;29(43):13465-72. 2009
IF : 7.452
Liens vers résumé
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| Lab |
Mouvement - Adaptation - Cognition - Jean-René Cazalets |
| Team |
Noyaux gris centraux, dynamiques et pathologiques - Christian Gross |
| Program areas |
Fonctions motrices normales et pathologiques ; Fonctions cognitives normales et pathologiques |
| National Collaboration |
- Institut du Cerveau et de la Moëlle épinière (CR-ICM), INSERM UMR 975, Centre de Neuroimagerie de Recherche (CENIR), Hôpital Pitié-Salpêtrière, F-75013 Paris, France
- Université Pierre et Marie Curie (Paris 6), F-75005 Paris, France
- Basal Gang, CNRS UMR 5227, Université Victor Segalen (Bordeaux 2), F-33076 Bordeaux, France
- CNRS UMR 8160, Université Lille Nord-de-France (Lille 3), F-59653 Villeneuve d'Asq, France |
| Abstract |
A main focus in economics is on binary choice situations, in which human agents have to choose between two alternative options. The classical view is that decision making consists of valuating each option, comparing the two expected values, and selecting the higher one. Some neural correlates of option values have been described in animals, but little is known about how they are represented in the human brain: are they integrated into a single center or distributed over different areas? To address this issue, we examined whether the expected values of two options, which were cued by visual symbols and chosen with either the left or right hand, could be distinguished using functional magnetic resonance imaging. The two options were linked to monetary rewards through probabilistic contingencies that subjects had to learn so as to maximize payoff. Learning curves were fitted with a standard computational model that updates, on a trial-by-trial basis, the value of the chosen option in proportion to a reward prediction error. Results show that during learning, left and right option values were specifically expressed in the contralateral ventral prefrontal cortex, regardless of the upcoming choice. We therefore suggest that expected values are represented in a distributed manner that respects the topography of the brain systems elicited by the available options. |
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